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Blocking H2A.Z Incorporation via Tip60 Inhibition Promotes Systems Consolidation of Fear Memory in Mice

Memory formation is a protracted process that initially involves the hippocampus and becomes increasingly dependent on the cortex over time, but the mechanisms of this transfer are unclear. We recently showed that hippocampal depletion of the histone variant H2A.Z enhances both recent and remote mem...

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Detalles Bibliográficos
Autores principales: Narkaj, Klotilda, Stefanelli, Gilda, Wahdan, Malak, Azam, Amber B., Ramzan, Firyal, Steininger, Carl Frank David, Walters, Brandon J., Zovkic, Iva B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Society for Neuroscience 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6223110/
https://www.ncbi.nlm.nih.gov/pubmed/30417078
http://dx.doi.org/10.1523/ENEURO.0378-18.2018