Cryo-EM structure of substrate-bound human telomerase holoenzyme

Telomerase adds telomeric repeats to chromosome ends to balance incomplete replication. Telomerase regulation is implicated in cancer, aging and other human diseases, but progress towards telomerase clinical manipulation is hampered by the lack of structural data. Here we present the cryo-electron m...

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Detalles Bibliográficos
Autores principales: Nguyen, Thi Hoang Duong, Tam, Jane, Wu, Robert A., Greber, Basil J., Toso, Daniel, Nogales, Eva, Collins, Kathleen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6223129/
https://www.ncbi.nlm.nih.gov/pubmed/29695869
http://dx.doi.org/10.1038/s41586-018-0062-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6223129/
https://www.ncbi.nlm.nih.gov/pubmed/29695869
http://dx.doi.org/10.1038/s41586-018-0062-x

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