Identification of new inhibitors of Mdm2–p53 interaction via pharmacophore and structure-based virtual screening

BACKGROUND: The tumor suppressor protein p53 plays an important role in preventing tumor formation and progression through its involvement in cell division control and initiation of apoptosis. Mdm2 protein controls the activity of p53 protein through working as ubiquitin E3 ligase promoting p53 degr...

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Detalles Bibliográficos
Autores principales: Atatreh, Noor, Ghattas, Mohammad A, Bardaweel, Sanaa K, Rawashdeh, Sara Al, Sorkhy, Mohammad Al
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2018
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6223338/
https://www.ncbi.nlm.nih.gov/pubmed/30464405
http://dx.doi.org/10.2147/DDDT.S182444

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6223338/
https://www.ncbi.nlm.nih.gov/pubmed/30464405
http://dx.doi.org/10.2147/DDDT.S182444

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