Cargando…

Identification of new inhibitors of Mdm2–p53 interaction via pharmacophore and structure-based virtual screening

BACKGROUND: The tumor suppressor protein p53 plays an important role in preventing tumor formation and progression through its involvement in cell division control and initiation of apoptosis. Mdm2 protein controls the activity of p53 protein through working as ubiquitin E3 ligase promoting p53 degr...

Descripción completa

Detalles Bibliográficos
Autores principales:	Atatreh, Noor, Ghattas, Mohammad A, Bardaweel, Sanaa K, Rawashdeh, Sara Al, Sorkhy, Mohammad Al
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Dove Medical Press 2018
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6223338/ https://www.ncbi.nlm.nih.gov/pubmed/30464405 http://dx.doi.org/10.2147/DDDT.S182444

Ejemplares similares

Discovery of new butyrylcholinesterase inhibitors via structure-based virtual screening
por: Atatreh, Noor, et al.
Publicado: (2019)

Druggability analysis and classification of protein tyrosine phosphatase active sites
por: Ghattas, Mohammad A, et al.
Publicado: (2016)

Structure-based assessment and druggability classification of protein–protein interaction sites
por: Alzyoud, Lara, et al.
Publicado: (2022)

The Discovery of Small Allosteric and Active Site Inhibitors of the SARS-CoV-2 Main Protease via Structure-Based Virtual Screening and Biological Evaluation
por: Mahgoub, Radwa E., et al.
Publicado: (2022)

Pharmacophore and Virtual Screening of JAK3 inhibitors
por: Rajeswari, Murugesan, et al.
Publicado: (2014)

Virtual Lead Identification of Farnesyltransferase Inhibitors Based on Ligand and Structure-Based Pharmacophore Techniques
por: Al-Balas, Qosay A., et al.
Publicado: (2013)

Allosteric Binding Sites of the SARS-CoV-2 Main Protease: Potential Targets for Broad-Spectrum Anti-Coronavirus Agents
por: Alzyoud, Lara, et al.
Publicado: (2022)

The Discovery of Potent SHP2 Inhibitors with Anti-Proliferative Activity in Breast Cancer Cell Lines
por: Ghemrawi, Rose, et al.
Publicado: (2022)

Identification of Novel HBV/HDV Entry Inhibitors by Pharmacophore- and QSAR-Guided Virtual Screening
por: Kirstgen, Michael, et al.
Publicado: (2021)

Identification of Human Dihydroorotate Dehydrogenase Inhibitor by a Pharmacophore-Based Virtual Screening Study
por: Galati, Salvatore, et al.
Publicado: (2022)

Identification of novel acetylcholinesterase inhibitors designed by pharmacophore-based virtual screening, molecular docking and bioassay
por: Jang, Cheongyun, et al.
Publicado: (2018)

Identification of Novel Mitochondrial Pyruvate Carrier Inhibitors by Homology Modeling and Pharmacophore-Based Virtual Screening
por: Hegazy, Lamees, et al.
Publicado: (2022)

Discovery of YopE Inhibitors by Pharmacophore-Based Virtual Screening and Docking
por: Ozbuyukkaya, Gizem, et al.
Publicado: (2013)

Molecular Modelling Study and Antibacterial Evaluation of Diphenylmethane Derivatives as Potential FabI Inhibitors
por: Hasan, Shaima, et al.
Publicado: (2023)

Identification of Novel Src Inhibitors: Pharmacophore-Based Virtual Screening, Molecular Docking and Molecular Dynamics Simulations
por: Zhang, Yi, et al.
Publicado: (2020)

Drug Design by Pharmacophore and Virtual Screening Approach
por: Giordano, Deborah, et al.
Publicado: (2022)

Controlled Release of Pyrimidine Compound Using Polymeric Coated ZIF-8 Metal-Organic Framework as Glucagon-Like Peptide-1 Receptor Agonist Carrier
por: AlNeyadi, Shaikha S., et al.
Publicado: (2020)

Pharmacophore Models and Pharmacophore-Based Virtual Screening: Concepts and Applications Exemplified on Hydroxysteroid Dehydrogenases
por: Kaserer, Teresa, et al.
Publicado: (2015)

Identification of Novel HIV 1- Protease Inhibitors: Application of Ligand and Structure Based Pharmacophore Mapping and Virtual Screening
por: Yadav, Divya, et al.
Publicado: (2012)

Identification of Novel Protein Kinase Receptor Type 2 Inhibitors Using Pharmacophore and Structure-Based Virtual Screening
por: Cruz, Josiane V., et al.
Publicado: (2018)

A new strategy based on pharmacophore-based virtual screening in adenosine deaminase inhibitors detection and in-vitro study
por: Bazl, Roya, et al.
Publicado: (2012)

Discovery of Potential M2 Channel Inhibitors Based on the Amantadine Scaffold via Virtual Screening and Pharmacophore Modeling
por: Tran, Linh, et al.
Publicado: (2011)

Combining docking with pharmacophore filtering for improved virtual screening
por: Peach, Megan L, et al.
Publicado: (2009)

Probabilistic Approach for Virtual Screening Based on Multiple Pharmacophores
por: Madzhidov, Timur I., et al.
Publicado: (2020)

Pharmacophore Based Virtual Screening Approach to Identify Selective PDE4B Inhibitors
por: Gaurav, Anand, et al.
Publicado: (2017)

Application of ensemble pharmacophore-based virtual screening to the discovery of novel antimitotic tubulin inhibitors
por: Gallego-Yerga, Laura, et al.
Publicado: (2021)

Identification of novel CDK2 inhibitors by a multistage virtual screening method based on SVM, pharmacophore and docking model
por: Liang, Jing-Wei, et al.
Publicado: (2019)

An Application of Fit Quality to Screen MDM2/p53 Protein-Protein Interaction Inhibitors
por: Xue, Xin, et al.
Publicado: (2018)

Virtual screening and pharmacophore studies for ftase inhibitors using Indian plant anticancer compounds database
por: Khan, Abdul Hafeez, et al.
Publicado: (2010)

Pharmacophore Modeling, Virtual Screening, and Molecular Docking Studies for Discovery of Novel Akt2 Inhibitors
por: Fei, Jia, et al.
Publicado: (2013)

Combinatorial Pharmacophore-Based 3D-QSAR Analysis and Virtual Screening of FGFR1 Inhibitors
por: Zhou, Nannan, et al.
Publicado: (2015)

Ligand Based Pharmacophore Modeling and Virtual Screening Studies to Design Novel HDAC2 Inhibitors
por: Kandakatla, Naresh, et al.
Publicado: (2014)

Structure-Based Pharmacophore Design and Virtual Screening for Novel Tubulin Inhibitors with Potential Anticancer Activity
por: Zhou, Yunjiang, et al.
Publicado: (2019)

Discovery of Monoacylglycerol Lipase (MAGL) Inhibitors Based on a Pharmacophore-Guided Virtual Screening Study
por: Jha, Vibhu, et al.
Publicado: (2020)

Pharmacophore-Based Virtual Screening and Experimental Validation of Pyrazolone-Derived Inhibitors toward Janus Kinases
por: Sanachai, Kamonpan, et al.
Publicado: (2022)

The Dual Interactions of p53 with MDM2 and p300: Implications for the Design of MDM2 Inhibitors
por: Kannan, Srinivasaraghavan, et al.
Publicado: (2019)

Structure Based Design, Synthesis, Pharmacophore Modeling, Virtual Screening, and Molecular Docking Studies for Identification of Novel Cyclophilin D Inhibitors
por: Valasani, Koteswara Rao, et al.
Publicado: (2014)

Identification of potent HDAC 2 inhibitors using E-pharmacophore modelling, structure-based virtual screening and molecular dynamic simulation
por: Pai, Padmini, et al.
Publicado: (2022)

3D-QSAR-Based Pharmacophore Modeling, Virtual Screening, and Molecular Dynamics Simulations for the Identification of Spleen Tyrosine Kinase Inhibitors
por: Kumar, Vikas, et al.
Publicado: (2022)

Pharmacophore and docking-based sequential virtual screening for the identification of novel Sigma 1 receptor ligands
por: Alamri, Mubarak A, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_ubtv2mlskenmv1gka9dg12skbg