Cargando…

Resveratrol, an activator of SIRT1, induces protective autophagy in non-small-cell lung cancer via inhibiting Akt/mTOR and activating p38-MAPK

BACKGROUND: Resveratrol, a natural polyphenolic phytoalexin, has potent anti-tumor activity. Recently, it was found to induce autophagy in cancer cells. However, the effects of resveratrol on autophagy in non-small-cell lung cancer (NSCLC) cells have not yet been clearly elucidated. MATERIALS AND ME...

Descripción completa

Detalles Bibliográficos
Autores principales:	Wang, Jing, Li, Jiamei, Cao, Naiqing, Li, Zhen, Han, Jingying, Li, Li
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Dove Medical Press 2018
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6223384/ https://www.ncbi.nlm.nih.gov/pubmed/30464525 http://dx.doi.org/10.2147/OTT.S159095

Ejemplares similares

Resveratrol protects early brain injury after subarachnoid hemorrhage by activating autophagy and inhibiting apoptosis mediated by the Akt/mTOR pathway
por: Guo, Dan, et al.
Publicado: (2018)

Autophagy Inhibits Inflammation via Down-Regulation of p38 MAPK/mTOR Signaling Cascade in Endothelial Cells
por: Zhou, Ling, et al.
Publicado: (2023)

Akt/mTOR Targeting Activity of Resveratrol Derivatives in Non-Small Lung Cancer
por: Innets, Bhurichaya, et al.
Publicado: (2022)

Resveratrol Activates Autophagy via the AKT/mTOR Signaling Pathway to Improve Cognitive Dysfunction in Rats With Chronic Cerebral Hypoperfusion
por: Wang, Nan, et al.
Publicado: (2019)

SIRT3 Protects Against Acute Kidney Injury via AMPK/mTOR-Regulated Autophagy
por: Zhao, Wenyu, et al.
Publicado: (2018)

Matrine exerts antitumor activity in cervical cancer by protective autophagy via the Akt/mTOR pathway in vitro and in vivo
por: Zhang, Fan, et al.
Publicado: (2022)

Autophagy activation promotes bevacizumab resistance in glioblastoma by suppressing Akt/mTOR signaling pathway
por: Huang, He, et al.
Publicado: (2018)

Resveratrol-Activated AMPK/SIRT1/Autophagy in Cellular Models of Parkinson's Disease
por: Wu, Yuncheng, et al.
Publicado: (2011)

Resveratrol Ameliorates Systemic Sclerosis via Suppression of Fibrosis and Inflammation Through Activation of SIRT1/mTOR Signaling
por: Yao, Qicen, et al.
Publicado: (2020)

Matrine exerts anti-breast cancer activity by mediating apoptosis and protective autophagy via the AKT/mTOR pathway in MCF-7 cells
por: Du, Jikun, et al.
Publicado: (2020)

Soy Isoflavones Protect Neuronal PC12 Cells against Hypoxic Damage through Nrf2 Activation and Suppression of p38 MAPK and AKT–mTOR Pathways
por: Zhang, Yongzhu, et al.
Publicado: (2022)

HERPUD1 promotes ovarian cancer cell survival by sustaining autophagy and inhibit apoptosis via PI3K/AKT/mTOR and p38 MAPK signaling pathways
por: Nie, Xin, et al.
Publicado: (2022)

Response to Article “Autophagy Inhibits Inflammation via Down-Regulation of p38 MAPK/mTOR Signaling Cascade in Endothelial Cells” [Response to Letter]
por: Zhou, Ling, et al.
Publicado: (2023)

Resveratrol Induces Autophagy and Apoptosis in Non-Small-Cell Lung Cancer Cells by Activating the NGFR-AMPK-mTOR Pathway
por: Li, Jiaqiao, et al.
Publicado: (2022)

Resveratrol induces autophagy by directly inhibiting mTOR through ATP competition
por: Park, Dohyun, et al.
Publicado: (2016)

CWHM-1008 Induces Apoptosis and Protective Autophagy through the Akt/mTOR Axis in LUAD Cells
por: Zhang, Jiao, et al.
Publicado: (2021)

Effects of Sirt3-autophagy and resveratrol activation on myocardial hypertrophy and energy metabolism
por: Wang, Hai-Ning, et al.
Publicado: (2020)

Resveratrol suppresses melanoma growth by promoting autophagy through inhibiting the PI3K/AKT/mTOR signaling pathway
por: Gong, Changhua, et al.
Publicado: (2020)

Orf virus induces complete autophagy to promote viral replication via inhibition of AKT/mTOR and activation of the ERK1/2/mTOR signalling pathway in OFTu cells
por: Lv, Lijun, et al.
Publicado: (2023)

Piperlongumine induces apoptosis and autophagy in leukemic cells through targeting the PI3K/Akt/mTOR and p38 signaling pathways
por: Wang, Hongfei, et al.
Publicado: (2018)

Curcumin induces apoptosis and autophagy inhuman renal cell carcinoma cells via Akt/mTOR suppression
por: Gong, Xuelian, et al.
Publicado: (2021)

Melatonin Attenuates Her-2, p38 MAPK, p-AKT, and mTOR Levels in Ovarian Carcinoma of Ethanol-Preferring Rats
por: Ferreira, Grazielle M., et al.
Publicado: (2014)

Akt and mTOR in B Cell Activation and Differentiation
por: Limon, Jose J., et al.
Publicado: (2012)

Beneficial Effects of Resveratrol-Mediated Inhibition of the mTOR Pathway in Spinal Cord Injury
por: Zhou, Jingying, et al.
Publicado: (2018)

Hyperbaric oxygen relieves neuropathic pain through AKT/TSC2/mTOR pathway activity to induce autophagy
por: Liu, Yong-Da, et al.
Publicado: (2019)

Inhibition of autophagy via activation of PI3K/Akt/mTOR pathway contributes to the protection of hesperidin against myocardial ischemia/reperfusion injury
por: Li, Xuefei, et al.
Publicado: (2018)

Prucalopride inhibits the glioma cells proliferation and induces autophagy via AKT-mTOR pathway
por: Qiao, Hong, et al.
Publicado: (2018)

Danlou Tablet Activates Autophagy of Vascular Adventitial Fibroblasts Through PI3K/Akt/mTOR to Protect Cells From Damage Caused by Atherosclerosis
por: Wang, Li, et al.
Publicado: (2021)

Apatinib induces apoptosis and autophagy via the PI3K/AKT/mTOR and MAPK/ERK signaling pathways in neuroblastoma
por: Yu, Xiying, et al.
Publicado: (2020)

Dihydroartemisinin Induces Endothelial Cell Autophagy through Suppression of the Akt/mTOR Pathway
por: Liu, Jing, et al.
Publicado: (2019)

The Roles of PI3K/AKT/mTOR and MAPK/ERK Signaling Pathways in Human Pheochromocytomas
por: Du, Juan, et al.
Publicado: (2016)

Activation of Akt/mTOR Pathway Is Associated with Poor Prognosis of Nasopharyngeal Carcinoma
por: Wang, Weiyuan, et al.
Publicado: (2014)

Resveratrol protects against atherosclerosis by downregulating the PI3K/AKT/mTOR signaling pathway in atherosclerosis model mice
por: Ji, Wuguang, et al.
Publicado: (2022)

Apatinib-induced protective autophagy and apoptosis through the AKT–mTOR pathway in anaplastic thyroid cancer
por: Feng, Haoran, et al.
Publicado: (2018)

Doxazosin Attenuates Liver Fibrosis by Inhibiting Autophagy in Hepatic Stellate Cells via Activation of the PI3K/Akt/mTOR Signaling Pathway
por: Xiu, Ai-Yuan, et al.
Publicado: (2021)

Matrine induces autophagy in human neuroblastoma cells via blocking the AKT-mTOR pathway
por: Liu, Nanjing, et al.
Publicado: (2022)

Response to Article “Autophagy Inhibits Inflammation via Down-Regulation of p38 MAPK/mTOR Signaling Cascade in Endothelial Cells” [Letter]
por: Maha, Masri Sembiring, et al.
Publicado: (2023)

Sinomenine ester derivative inhibits glioblastoma by inducing mitochondria-dependent apoptosis and autophagy by PI3K/AKT/mTOR and AMPK/mTOR pathway
por: Zheng, Xiangjin, et al.
Publicado: (2021)

Cornin protects against cerebral ischemia/reperfusion injury by preventing autophagy via the PI3K/Akt/mTOR pathway
por: Lan, Tianchi, et al.
Publicado: (2022)

The Roles of Autophagy, Mitophagy, and the Akt/mTOR Pathway in the Pathogenesis of Chronic Rhinosinusitis with Nasal Polyps
por: Wang, Chen, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_8p2fkmf9qnq2p9qumm4nfbd1g8