Gemcabene, a first-in-class lipid-lowering agent in late-stage development, down-regulates acute-phase C-reactive protein via C/EBP-δ-mediated transcriptional mechanism

Inflammation plays a key role in setting the stage leading to atherosclerosis progression, and high-sensitivity C-reactive protein (CRP) has been recognized as a predictor of cardiovascular risk. As a monotherapy and in combination with statins, gemcabene markedly reduced CRP in humans. Present inve...

Descripción completa

Detalles Bibliográficos
Autores principales: Srivastava, Rai Ajit K., Cornicelli, Joseph A., Markham, Bruce, Bisgaier, Charles L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6223808/
https://www.ncbi.nlm.nih.gov/pubmed/29644527
http://dx.doi.org/10.1007/s11010-018-3353-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6223808/
https://www.ncbi.nlm.nih.gov/pubmed/29644527
http://dx.doi.org/10.1007/s11010-018-3353-5

Ejemplares similares