Ehrlichia chaffeensis TRP47 enters the nucleus via a MYND-binding domain-dependent mechanism and predominantly binds enhancers of host genes associated with signal transduction, cytoskeletal organization, and immune response

Ehrlichia chaffeensis is an obligately intracellular bacterium that establishes infection in mononuclear phagocytes through largely undefined reprogramming strategies including modulation of host gene transcription. In this study, we demonstrate that the E. chaffeensis effector TRP47 enters the host...

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Detalles Bibliográficos
Autores principales: Kibler, Clayton E., Milligan, Sarah L., Farris, Tierra R., Zhu, Bing, Mitra, Shubhajit, McBride, Jere W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6224051/
https://www.ncbi.nlm.nih.gov/pubmed/30408047
http://dx.doi.org/10.1371/journal.pone.0205983

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6224051/
https://www.ncbi.nlm.nih.gov/pubmed/30408047
http://dx.doi.org/10.1371/journal.pone.0205983

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