Molecular characterisation of atypical BSE prions by mass spectrometry and changes following transmission to sheep and transgenic mouse models

The prion hypothesis proposes a causal relationship between the misfolded prion protein (PrP(Sc)) molecular entity and the disease transmissible spongiform encephalopathy (TSE). Variations in the conformation of PrP(Sc) are associated with different forms of TSE and different risks to animal and hum...

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Detalles Bibliográficos
Autores principales: Gielbert, Adriana, Thorne, Jemma K., Plater, Jane M., Thorne, Leigh, Griffiths, Peter C., Simmons, Marion M., Cassar, Claire A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6224059/
https://www.ncbi.nlm.nih.gov/pubmed/30408075
http://dx.doi.org/10.1371/journal.pone.0206505

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6224059/
https://www.ncbi.nlm.nih.gov/pubmed/30408075
http://dx.doi.org/10.1371/journal.pone.0206505

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