Age-dependent methylation in epigenetic clock CpGs is associated with G-quadruplex, co-transcriptionally formed RNA structures and tentative splice sites

Horvath’s epigenetic clock consists of 353 CpGs whose methylation levels can accurately predict the age of individuals. Using bioinformatics analysis, we investigated the conformation, energy characteristics and presence of tentative splice sites of the sequences surrounding the epigenetic clock CpG...

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Detalles Bibliográficos
Autores principales: Malousi, Andigoni, Andreou, Alexandra-Zoi, Georgiou, Elisavet, Tzimagiorgis, Georgios, Kovatsi, Leda, Kouidou, Sofia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2018
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6224212/
https://www.ncbi.nlm.nih.gov/pubmed/30270726
http://dx.doi.org/10.1080/15592294.2018.1514232

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6224212/
https://www.ncbi.nlm.nih.gov/pubmed/30270726
http://dx.doi.org/10.1080/15592294.2018.1514232

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