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Conformation-specific detection of calmodulin binding using the unnatural amino acid p-azido-phenylalanine (AzF) as an IR-sensor

Calmodulin (CaM) is a very conserved, ubiquitous, eukaryotic protein that binds four Ca(2+) ions with high affinity. It acts as a calcium sensor by translating Ca(2+) signals into cellular processes such as metabolism, inflammation, immune response, memory, and muscle contraction. Calcium binding to...

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Detalles Bibliográficos
Autores principales: Creon, Anne, Josts, Inokentijs, Niebling, Stephan, Huse, Nils, Tidow, Henning
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Crystallographic Association 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6224318/
https://www.ncbi.nlm.nih.gov/pubmed/30474048
http://dx.doi.org/10.1063/1.5053466