Cargando…

The Emerging Role of Lamin C as an Important LMNA Isoform in Mechanophenotype

Lamin A and lamin C isoforms of the gene LMNA are major structural and mechanotransductive components of the nuclear lamina. Previous reports have proposed lamin A as the isoform with the most dominant contributions to cellular mechanophenotype. Recently, expression of lamin C has also been shown to...

Descripción completa

Detalles Bibliográficos
Autores principales:	González-Cruz, Rafael D., Dahl, Kris N., Darling, Eric M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2018
Materias:	Physiology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6224339/ https://www.ncbi.nlm.nih.gov/pubmed/30450357 http://dx.doi.org/10.3389/fcell.2018.00151

Ejemplares similares

Microparticles with tunable, cell-like properties for quantitative acoustic mechanophenotyping
por: Dubay, Ryan, et al.
Publicado: (2023)

The R439C mutation in LMNA causes lamin oligomerization and susceptibility to oxidative stress
por: Verstraeten, Valerie LRM, et al.
Publicado: (2009)

Cardiomyocyte-Specific Expression of Lamin A Improves Cardiac Function in Lmna (−/−) Mice
por: Frock, Richard L., et al.
Publicado: (2012)

The Broad Spectrum of LMNA Cardiac Diseases: From Molecular Mechanisms to Clinical Phenotype
por: Crasto, Silvia, et al.
Publicado: (2020)

PINCH1 Promotes Fibroblast Migration in Extracellular Matrices and Influences Their Mechanophenotype
por: Mierke, Claudia Tanja, et al.
Publicado: (2022)

Role of Lamin A/C Gene Mutations in the Signaling Defects Leading to Cardiomyopathies
por: Gerbino, Andrea, et al.
Publicado: (2018)

A truncated lamin A in the Lmna(−/−) mouse line: Implications for the understanding of laminopathies
por: Jahn, Daniel, et al.
Publicado: (2012)

Correction: Cardiomyocyte-Specific Expression of Lamin A Improves Cardiac Function in Lmna (−/−) Mice
por: Frock, Richard L., et al.
Publicado: (2012)

Single-Cell Mechanophenotyping in Microfluidics to Evaluate Behavior of U87 Glioma Cells
por: Sengul, Esra, et al.
Publicado: (2020)

Phenotypic Variability in iPSC-Induced Cardiomyocytes and Cardiac Fibroblasts Carrying Diverse LMNA Mutations
por: Yang, Jiajia, et al.
Publicado: (2021)

Effects of mutant lamins on nucleo-cytoskeletal coupling in Drosophila models of LMNA muscular dystrophy
por: Shaw, Nicholas M., et al.
Publicado: (2022)

Corrigendum: Phenotypic variability in iPSC-induced cardiomyocytes and cardiac fibroblasts carrying diverse LMNA mutations
por: Yang, Jiajia, et al.
Publicado: (2022)

High-throughput mechanophenotyping of multicellular spheroids using a microfluidic micropipette aspiration chip
por: Boot, Ruben C., et al.
Publicado: (2023)

Modeling Skeletal Muscle Laminopathies Using Human Induced Pluripotent Stem Cells Carrying Pathogenic LMNA Mutations
por: Steele-Stallard, Heather B., et al.
Publicado: (2018)

The role of ADAM8 in the mechanophenotype of MDA-MB-231 breast cancer cells in 3D extracellular matrices
por: Hayn, Alexander, et al.
Publicado: (2023)

Mutations in LMNA Modulate the Lamin A - Nesprin-2 Interaction and Cause LINC Complex Alterations
por: Yang, Liu, et al.
Publicado: (2013)

Revisiting the truncated lamin A produced by a commonly used strain of Lmna knockout mice
por: Kim, Joonyoung R., et al.
Publicado: (2023)

Deficient Lmna in fibroblasts: an emerging role of non-cardiomyocytes in DCM
por: Wang, Xinjie, et al.
Publicado: (2022)

Refractory ventricular arrhythmia in a patient with Lamin A/C (LMNA) cardiomyopathy successfully treated with thoracic bilateral stellate ganglionectomy
por: Okeagu, Eze, et al.
Publicado: (2021)

Mechanisms of A-Type Lamin Targeting to Nuclear Ruptures Are Disrupted in LMNA- and BANF1-Associated Progerias
por: Sears, Rhiannon M., et al.
Publicado: (2022)

Ex vivo anticoagulants affect human blood platelet biomechanics with implications for high-throughput functional mechanophenotyping
por: Sachs, Laura, et al.
Publicado: (2022)

Systematic in vivo candidate evaluation uncovers therapeutic targets for LMNA dilated cardiomyopathy and risk of Lamin A toxicity
por: Tan, Chia Yee, et al.
Publicado: (2023)

Nesprins and Lamins in Health and Diseases of Cardiac and Skeletal Muscles
por: Janin, Alexandre, et al.
Publicado: (2018)

Lamin A/C Assembly Defects in LMNA-Congenital Muscular Dystrophy Is Responsible for the Increased Severity of the Disease Compared with Emery–Dreifuss Muscular Dystrophy
por: Bertrand, Anne T., et al.
Publicado: (2020)

Effect of Occurrence of Lamin A/C (LMNA) Genetic Variants in a Cohort of 101 Consecutive Apparent “Lone AF” Patients: Results and Insights
por: Pessente, Gabrielle D'Arezzo, et al.
Publicado: (2022)

A heterozygous p.S143P mutation in LMNA associates with proteasome dysfunction and enhanced autophagy-mediated degradation of mutant lamins A and C
por: West, Gun, et al.
Publicado: (2022)

Statins and Histone Deacetylase Inhibitors Affect Lamin A/C – Histone Deacetylase 2 Interaction in Human Cells
por: Mattioli, Elisabetta, et al.
Publicado: (2019)

Body Composition And Bone Mineral Differences According to Lamin A (LMNA) Genotype in Familial Partial Lipodystrophy Type 2
por: de Freitas, Maria Cristina Foss, et al.
Publicado: (2021)

Author Correction: Ex vivo anticoagulants affect human blood platelet biomechanics with implications for high-throughput functional mechanophenotyping
por: Sachs, Laura, et al.
Publicado: (2022)

Involvement of the Lamin Rod Domain in Heterotypic Lamin Interactions Important for Nuclear Organization
por: Schirmer, Eric C., et al.
Publicado: (2001)

Mechanophenotyping of B16 Melanoma Cell Variants for the Assessment of the Efficacy of (-)-Epigallocatechin Gallate Treatment Using a Tapered Microfluidic Device
por: Nakamura, Masanori, et al.
Publicado: (2019)

NFAT5 Isoform C Controls Biomechanical Stress Responses of Vascular Smooth Muscle Cells
por: Zappe, Maren, et al.
Publicado: (2018)

LMNA-related dilated cardiomyopathy
por: Vaikhanskaya, Tatiyana, et al.
Publicado: (2014)

Epigenetics in LMNA-Related Cardiomyopathy
por: Wang, Yinuo, et al.
Publicado: (2023)

Integrated analysis reveals the alterations that LMNA interacts with euchromatin in LMNA mutation-associated dilated cardiomyopathy
por: Zhang, Xiaolin, et al.
Publicado: (2021)

Novel mutations in LMNA A/C gene and associated phenotypes
por: Petillo, Roberta, et al.
Publicado: (2015)

A novel LMNA mutation identified in a Japanese patient with LMNA-associated congenital muscular dystrophy
por: Ishiyama, Akihiko, et al.
Publicado: (2018)

Emerging Roles in the Biogenesis of Cytochrome c Oxidase for Members of the Mitochondrial Carrier Family
por: Ogunbona, Oluwaseun B., et al.
Publicado: (2019)

Managing Brain Extracellular K(+) during Neuronal Activity: The Physiological Role of the Na(+)/K(+)-ATPase Subunit Isoforms
por: Larsen, Brian Roland, et al.
Publicado: (2016)

STIM and Orai isoform expression in pregnant human myometrium: a potential role in calcium signaling during pregnancy
por: Chin-Smith, Evonne C., et al.
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_gf3ohqqno1aptj8l5qmfied2h6