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Regenerative Approaches in Huntington’s Disease: From Mechanistic Insights to Therapeutic Protocols
Huntington’s Disease (HD) is a neurodegenerative disorder caused by a CAG expansion in the exon-1 of the IT15 gene encoding the protein Huntingtin. Expression of mutated Huntingtin in humans leads to dysfunction and ultimately degeneration of selected neuronal populations of the striatum and cerebra...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Frontiers Media S.A.
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6224350/ https://www.ncbi.nlm.nih.gov/pubmed/30450032 http://dx.doi.org/10.3389/fnins.2018.00800 |