Autocrine Tnf signaling favors malignant cells in myelofibrosis in a Tnfr2-dependent fashion

Tumor necrosis factor alpha (TNF) is increased in myelofibrosis (MF) and promotes survival of malignant over normal cells. The mechanisms altering TNF responsiveness in MF cells are unknown. We show that the proportion of marrow (BM) cells expressing TNF is increased in MF compared to controls, with...

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Detalles Bibliográficos
Autores principales: Heaton, William L., Senina, Anna V., Pomicter, Anthony D., Salama, Mohamed E., Clair, Phillip M., Yan, Dongqing, Bell, Russell N., Gililland, Jeremy M., Prchal, Josef T., O’Hare, Thomas, Deininger, Michael W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6224399/
https://www.ncbi.nlm.nih.gov/pubmed/29749399
http://dx.doi.org/10.1038/s41375-018-0131-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6224399/
https://www.ncbi.nlm.nih.gov/pubmed/29749399
http://dx.doi.org/10.1038/s41375-018-0131-z

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