PIM2-mediated phosphorylation of hexokinase 2 is critical for tumor growth and paclitaxel resistance in breast cancer

Hexokinase-II (HK2) is a key enzyme involved in glycolysis, which is required for breast cancer progression. However, the underlying post-translational mechanisms of HK2 activity are poorly understood. Here, we showed that Proviral Insertion in Murine Lymphomas 2 (PIM2) directly bound to HK2 and pho...

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Detalles Bibliográficos
Autores principales: Yang, Tingting, Ren, Chune, Qiao, Pengyun, Han, Xue, Wang, Li, Lv, Shijun, Sun, Yonghong, Liu, Zhijun, Du, Yu, Yu, Zhenhai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6224402/
https://www.ncbi.nlm.nih.gov/pubmed/29985480
http://dx.doi.org/10.1038/s41388-018-0386-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6224402/
https://www.ncbi.nlm.nih.gov/pubmed/29985480
http://dx.doi.org/10.1038/s41388-018-0386-x

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