Kinase domain activation through gene rearrangement in multiple myeloma

Chromosomal rearrangements that result in oncogenic kinase activation are present in many solid and hematological malignancies, but none have been reported in multiple myeloma (MM). Here we analyzed 1421 samples from 958 myeloma patients using a targeted assay and detected fusion genes in 1.5% of pa...

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Detalles Bibliográficos
Autores principales: Morgan, Gareth J, He, Jie, Tytarenko, Ruslana, Patel, Purvi, Stephens, Owen W, Zhong, Shan, Deshpande, Shayu, Bauer, Michael, Weinhold, Niels, Schinke, Carolina, Rasche, Leo, Bailey, Mark, Ali, Siraj, Ross, Jeff, Miller, Vincent A, Stephens, Phillip, Thanendrarajan, Sharmilan, Zangari, Maurizio, van Rhee, Frits, Mughal, Tariq, Davies, Faith E, Walker, Brian A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6224403/
https://www.ncbi.nlm.nih.gov/pubmed/29654269
http://dx.doi.org/10.1038/s41375-018-0108-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6224403/
https://www.ncbi.nlm.nih.gov/pubmed/29654269
http://dx.doi.org/10.1038/s41375-018-0108-y

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