A rapamycin derivative, biolimus, preferentially activates autophagy in vascular smooth muscle cells

Although rapamycin is a well-known conformational inhibitor of mTORC1, it is now widely used for treating arterial restenosis. Various rapamycin analogues (rapalogue) have been made for applying to drug-eluting stents. Here we show that two major rapalogues, everolimus and biolimus, exert a differen...

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Detalles Bibliográficos
Autores principales: Kim, Yerin, Park, Jun Kyu, Seo, Jun-Hyuk, Ryu, Hyun-Seung, Lim, Kyung Seob, Jeong, Myung Ho, Kang, Dong Hoon, Kang, Sang Won
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6224423/
https://www.ncbi.nlm.nih.gov/pubmed/30410117
http://dx.doi.org/10.1038/s41598-018-34877-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6224423/
https://www.ncbi.nlm.nih.gov/pubmed/30410117
http://dx.doi.org/10.1038/s41598-018-34877-8

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