FXR agonist obeticholic acid induces liver growth but exacerbates biliary injury in rats with obstructive cholestasis

Cholestasis impairs liver regeneration following partial liver resection (PHx). Bile acid receptor farnesoid X-receptor (FXR) is a key mediator of liver regeneration. The effects of FXR agonist obeticholic acid (OCA) on liver (re)growth were therefore studied in cholestatic rats. Animals underwent s...

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Detalles Bibliográficos
Autores principales: van Golen, Rowan F., Olthof, Pim B., Lionarons, Daniël A., Reiniers, Megan J., Alles, Lindy K., Uz, Zehra, de Haan, Lianne, Ergin, Bulent, de Waart, Dirk R., Maas, Adrie, Verheij, Joanne, Jansen, Peter L., Damink, Steven W. Olde, Schaap, Frank G., van Gulik, Thomas M., Heger, Michal
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6224438/
https://www.ncbi.nlm.nih.gov/pubmed/30409980
http://dx.doi.org/10.1038/s41598-018-33070-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6224438/
https://www.ncbi.nlm.nih.gov/pubmed/30409980
http://dx.doi.org/10.1038/s41598-018-33070-1

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