Insights into Kinesin-1 Activation from the Crystal Structure of KLC2 Bound to JIP3

Kinesin-1 transports numerous cellular cargoes along microtubules. The kinesin-1 light chain (KLC) mediates cargo binding and regulates kinesin-1 motility. To investigate the molecular basis for kinesin-1 recruitment and activation by cargoes, we solved the crystal structure of the KLC2 tetratricope...

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Detalles Bibliográficos
Autores principales: Cockburn, Joseph J.B., Hesketh, Sophie J., Mulhair, Peter, Thomsen, Maren, O'Connell, Mary J., Way, Michael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6224480/
https://www.ncbi.nlm.nih.gov/pubmed/30197037
http://dx.doi.org/10.1016/j.str.2018.07.011

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6224480/
https://www.ncbi.nlm.nih.gov/pubmed/30197037
http://dx.doi.org/10.1016/j.str.2018.07.011

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