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Insights into Kinesin-1 Activation from the Crystal Structure of KLC2 Bound to JIP3
Kinesin-1 transports numerous cellular cargoes along microtubules. The kinesin-1 light chain (KLC) mediates cargo binding and regulates kinesin-1 motility. To investigate the molecular basis for kinesin-1 recruitment and activation by cargoes, we solved the crystal structure of the KLC2 tetratricope...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Cell Press
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6224480/ https://www.ncbi.nlm.nih.gov/pubmed/30197037 http://dx.doi.org/10.1016/j.str.2018.07.011 |