Structure of the 4-1BB/4-1BBL complex and distinct binding and functional properties of utomilumab and urelumab

4-1BB (CD137, TNFRSF9) is an inducible costimulatory receptor expressed on activated T cells. Clinical trials of two agonist antibodies, utomilumab (PF-05082566) and urelumab (BMS-663513), are ongoing in multiple cancer indications, and both antibodies demonstrate distinct activities in the clinic....

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Detalles Bibliográficos
Autores principales: Chin, S. Michael, Kimberlin, Christopher R., Roe-Zurz, Zygy, Zhang, Pamela, Xu, Allison, Liao-Chan, Sindy, Sen, Debasish, Nager, Andrew R., Oakdale, Nicole Schirle, Brown, Colleen, Wang, Feng, Yang, Yuting, Lindquist, Kevin, Yeung, Yik Andy, Salek-Ardakani, Shahram, Chaparro-Riggers, Javier
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6224509/
https://www.ncbi.nlm.nih.gov/pubmed/30410017
http://dx.doi.org/10.1038/s41467-018-07136-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6224509/
https://www.ncbi.nlm.nih.gov/pubmed/30410017
http://dx.doi.org/10.1038/s41467-018-07136-7

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