TGF-β-associated extracellular matrix genes link cancer-associated fibroblasts to immune evasion and immunotherapy failure

The extracellular matrix (ECM) is a key determinant of cancer progression and prognosis. Here we report findings from one of the largest pan-cancer analyses of ECM gene dysregulation in cancer. We define a distinct set of ECM genes upregulated in cancer (C-ECM) and linked to worse prognosis. We foun...

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Detalles Bibliográficos
Autores principales: Chakravarthy, Ankur, Khan, Lubaba, Bensler, Nathan Peter, Bose, Pinaki, De Carvalho, Daniel D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6224529/
https://www.ncbi.nlm.nih.gov/pubmed/30410077
http://dx.doi.org/10.1038/s41467-018-06654-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6224529/
https://www.ncbi.nlm.nih.gov/pubmed/30410077
http://dx.doi.org/10.1038/s41467-018-06654-8

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