Bleomycin-induced genome structural variations in normal, non-tumor cells

Many anticancer drugs are genotoxic agents inducing DNA breaks in actively proliferating cancer cells. However, these same drugs also induce mutations, mostly genome structural variations (GSVs). The detection of GSVs in normal cells and tissues is a major challenge due to the very low abundance of...

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Detalles Bibliográficos
Autores principales: Quispe-Tintaya, Wilber, Lee, Moonsook, Dong, Xiao, Weiser, Daniel A., Vijg, Jan, Maslov, Alexander Y.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6224559/
https://www.ncbi.nlm.nih.gov/pubmed/30410071
http://dx.doi.org/10.1038/s41598-018-34580-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6224559/
https://www.ncbi.nlm.nih.gov/pubmed/30410071
http://dx.doi.org/10.1038/s41598-018-34580-8

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