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Mapping the Ligand Binding Landscape
The interaction between a ligand and a protein involves a multitude of conformational states. To achieve a particular deeply bound pose, the ligand must search across a rough free-energy landscape with many metastable minima. Creating maps of the ligand binding landscape is a great challenge, as bin...
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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The Biophysical Society
2018
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6224774/ https://www.ncbi.nlm.nih.gov/pubmed/30327139 http://dx.doi.org/10.1016/j.bpj.2018.09.021 |