RNAi-Mediated β-Catenin Inhibition Promotes T Cell Infiltration and Antitumor Activity in Combination with Immune Checkpoint Blockade

Wnt/β-catenin signaling mediates cancer immune evasion and resistance to immune checkpoint therapy, in part by blocking cytokines that trigger immune cell recruitment. Inhibition of β-catenin may be an effective strategy for increasing the low response rate to these effective medicines in numerous c...

Descripción completa

Detalles Bibliográficos
Autores principales: Ganesh, Shanthi, Shui, Xue, Craig, Kevin P., Park, Jihye, Wang, Weimin, Brown, Bob D., Abrams, Marc T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2018
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6225018/
https://www.ncbi.nlm.nih.gov/pubmed/30274786
http://dx.doi.org/10.1016/j.ymthe.2018.09.005

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6225018/
https://www.ncbi.nlm.nih.gov/pubmed/30274786
http://dx.doi.org/10.1016/j.ymthe.2018.09.005

Ejemplares similares