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RNAi-Mediated β-Catenin Inhibition Promotes T Cell Infiltration and Antitumor Activity in Combination with Immune Checkpoint Blockade

Wnt/β-catenin signaling mediates cancer immune evasion and resistance to immune checkpoint therapy, in part by blocking cytokines that trigger immune cell recruitment. Inhibition of β-catenin may be an effective strategy for increasing the low response rate to these effective medicines in numerous c...

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Detalles Bibliográficos
Autores principales:	Ganesh, Shanthi, Shui, Xue, Craig, Kevin P., Park, Jihye, Wang, Weimin, Brown, Bob D., Abrams, Marc T.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society of Gene & Cell Therapy 2018
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6225018/ https://www.ncbi.nlm.nih.gov/pubmed/30274786 http://dx.doi.org/10.1016/j.ymthe.2018.09.005

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