Probing the Anticancer Action of Novel Ferrocene Analogues of MNK Inhibitors

Two novel ferrocene-containing compounds based upon a known MNK1/2 kinase (MAPK-interacting kinase) inhibitor have been synthesized. The compounds were designed to use the unique shape of ferrocene to exploit a large hydrophobic pocket in MNK1/2 that is only partially occupied by the original compou...

Descripción completa

Detalles Bibliográficos
Autores principales: Sansook, Supojjanee, Lineham, Ella, Hassell-Hart, Storm, Tizzard, Graham J., Coles, Simon J., Spencer, John, Morley, Simon J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6225114/
https://www.ncbi.nlm.nih.gov/pubmed/30142961
http://dx.doi.org/10.3390/molecules23092126

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6225114/
https://www.ncbi.nlm.nih.gov/pubmed/30142961
http://dx.doi.org/10.3390/molecules23092126

Ejemplares similares