A New Chemoenzymatic Synthesis of the Chiral Key Intermediate of the Antiepileptic Brivaracetam

Brivaracetam is a new anticonvulsant compound, recently approved as an antiepileptic drug. This drug substance presents a 4-substituted pyrrolidone structure: the (4R)-configuration of the stereocenter present on the heterocyclic ring is the main target of the synthesis. The described method allows...

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Detalles Bibliográficos
Autores principales: Ciceri, Samuele, Grisenti, Paride, Reza Elahi, Shahrzad, Ferraboschi, Patrizia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6225152/
https://www.ncbi.nlm.nih.gov/pubmed/30200322
http://dx.doi.org/10.3390/molecules23092206

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6225152/
https://www.ncbi.nlm.nih.gov/pubmed/30200322
http://dx.doi.org/10.3390/molecules23092206

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