Phosphate-Catalyzed Succinimide Formation from an NGR-Containing Cyclic Peptide: A Novel Mechanism for Deammoniation of the Tetrahedral Intermediate

Spontaneous deamidation in the Asn-Gly-Arg (NGR) motif that yields an isoAsp-Gly-Arg (isoDGR) sequence has recently attracted considerable attention because of the possibility of application to dual tumor targeting. It is well known that Asn deamidation reactions in peptide chains occur via the five...

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Detalles Bibliográficos
Autores principales: Kirikoshi, Ryota, Manabe, Noriyoshi, Takahashi, Ohgi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6225186/
https://www.ncbi.nlm.nih.gov/pubmed/30200364
http://dx.doi.org/10.3390/molecules23092217

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6225186/
https://www.ncbi.nlm.nih.gov/pubmed/30200364
http://dx.doi.org/10.3390/molecules23092217

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