Characterisation of the Structure and Oligomerisation of Islet Amyloid Polypeptides (IAPP): A Review of Molecular Dynamics Simulation Studies

Human islet amyloid polypeptide (hIAPP) is a naturally occurring, intrinsically disordered protein whose abnormal aggregation into amyloid fibrils is a pathological feature in type 2 diabetes, and its cross-aggregation with amyloid beta has been linked to an increased risk of Alzheimer’s disease. Th...

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Detalles Bibliográficos
Autores principales: Moore, Sandra J., Sonar, Krushna, Bharadwaj, Prashant, Deplazes, Evelyne, Mancera, Ricardo L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6225196/
https://www.ncbi.nlm.nih.gov/pubmed/30149632
http://dx.doi.org/10.3390/molecules23092142

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6225196/
https://www.ncbi.nlm.nih.gov/pubmed/30149632
http://dx.doi.org/10.3390/molecules23092142

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