Asymmetric Synthesis of (−)-6-Desmethyl-Fluvirucinine A(1) via Conformationally-Controlled Diastereoselective Lactam-Ring Expansions

The versatile synthesis of (−)-6-desmethyl-fluvirucinine A(1) was accomplished at a 24% overall yield through a thirteen-step process from a known vinylpiperidine. The key part involved the elaboration of the distal stereocenters and a macrolactam skeleton via conformationally-induced diastereocontr...

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Detalles Bibliográficos
Autores principales: Moon, Hyunyoung, Yoon, Hojong, Lim, Changjin, Jang, Jaebong, Yi, Jong-Jae, Lee, Jae Kyun, Lee, Jeeyeon, Na, Younghwa, Son, Woo Sung, Kim, Seok-Ho, Suh, Young-Ger
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6225218/
https://www.ncbi.nlm.nih.gov/pubmed/30223428
http://dx.doi.org/10.3390/molecules23092351

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6225218/
https://www.ncbi.nlm.nih.gov/pubmed/30223428
http://dx.doi.org/10.3390/molecules23092351

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