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Asymmetric Synthesis of (−)-6-Desmethyl-Fluvirucinine A(1) via Conformationally-Controlled Diastereoselective Lactam-Ring Expansions
The versatile synthesis of (−)-6-desmethyl-fluvirucinine A(1) was accomplished at a 24% overall yield through a thirteen-step process from a known vinylpiperidine. The key part involved the elaboration of the distal stereocenters and a macrolactam skeleton via conformationally-induced diastereocontr...
| Autores principales: | , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
MDPI
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6225218/ https://www.ncbi.nlm.nih.gov/pubmed/30223428 http://dx.doi.org/10.3390/molecules23092351 |