Cargando…

Imaging of Human Insulin Secreting Cells with Gd-DOTA-P88, a Paramagnetic Contrast Agent Targeting the Beta Cell Biomarker FXYD2γa

Non-invasive imaging and quantification of human beta cell mass remains a major challenge. We performed pre-clinical in vivo validation of a peptide previously discovered by our group, namely, P88 that targets a beta cell specific biomarker, FXYD2γa. We conjugated P88 with DOTA and then complexed it...

Descripción completa

Detalles Bibliográficos
Autores principales:	Demine, Stéphane, Balhuizen, Alexander, Debaille, Vinciane, Joosten, Lieke, Fereau, Maïté, Chilla, Satya Narayana Murthy, Millard, Isabelle, Scharfmann, Raphaël, Egrise, Dominique, Goldman, Serge, Marchetti, Piero, Gotthardt, Martin, Laurent, Sophie, Burtea, Carmen, Eizirik, Decio L.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6225257/ https://www.ncbi.nlm.nih.gov/pubmed/30134599 http://dx.doi.org/10.3390/molecules23092100

Ejemplares similares

Strain Differences Determine the Suitability of Animal Models for Noninvasive In Vivo Beta Cell Mass Determination with Radiolabeled Exendin
por: Willekens, Stefanie M. A., et al.
Publicado: (2016)

A nanobody-based tracer targeting DPP6 for non-invasive imaging of human pancreatic endocrine cells
por: Balhuizen, Alexander, et al.
Publicado: (2017)

Improved labelling of DTPA- and DOTA-conjugated peptides and antibodies with (111)In in HEPES and MES buffer
por: Brom, Maarten, et al.
Publicado: (2012)

Trivalent Gd-DOTA reagents for modification of proteins
por: Fisher, Martin J., et al.
Publicado: (2015)

Beta Cell Imaging—From Pre-Clinical Validation to First in Man Testing
por: Demine, Stephane, et al.
Publicado: (2020)

What FXYDs fix
por: Habeck, Michael, et al.
Publicado: (2021)

The effects of three different contrast agents (Gd-BOPTA, Gd-DTPA, and Gd-DOTA) on brachial plexus magnetic resonance imaging
por: Zhang, Xiaojing, et al.
Publicado: (2021)

Gd(III)-DOTA-modified sonosensitive liposomes for ultrasound-triggered release and MR imaging
por: Jung, Suk Hyun, et al.
Publicado: (2012)

Pro-inflammatory cytokines induce cell death, inflammatory responses, and endoplasmic reticulum stress in human iPSC-derived beta cells
por: Demine, Stéphane, et al.
Publicado: (2020)

Gd(III)–Gd(III) Relaxation-Induced Dipolar Modulation Enhancement for In-Cell Electron Paramagnetic Resonance Distance Determination
por: Azarkh, Mykhailo, et al.
Publicado: (2019)

Impaired AQP2 trafficking in Fxyd1 knockout mice: A role for FXYD1 in regulated vesicular transport
por: Arystarkhova, Elena, et al.
Publicado: (2017)

Displacement of Native FXYD Protein From Na(+)/K(+)-ATPase With Novel FXYD Peptide Derivatives: Effects on Doxorubicin Cytotoxicity
por: Liu, Chia-Chi, et al.
Publicado: (2022)

Polymeric Gd-DOTA amphiphiles form spherical and fibril-shaped nanoparticle MRI contrast agents
por: Randolph, Lyndsay M., et al.
Publicado: (2016)

FXYD6 is a new biomarker of cholangiocarcinoma
por: CHEN, XIONGFEI, et al.
Publicado: (2014)

FXYD proteins and sodium pump regulatory mechanisms
por: Yap, John Q., et al.
Publicado: (2021)

FXYD3: A Promising Biomarker for Urothelial Carcinoma
por: Zhang, ZhongFa, et al.
Publicado: (2011)

Expression and clinical significance of FXYD3 in endometrial cancer
por: LI, YIFEI, et al.
Publicado: (2014)

Expression and Significance of FXYD-3 Protein in Gastric Adenocarcinoma
por: Zhu, Zhen-Long, et al.
Publicado: (2010)

Postaurical injection is a systemic delivery supported by symmetric distribution of Gd-DOTA in both the ipsilateral and contralateral ears()
por: Zou, Jing
Publicado: (2015)

Bifunctional Paramagnetic and Luminescent Clays Obtained by Incorporation of Gd(3+) and Eu(3+) Ions in the Saponite Framework
por: Marchesi, Stefano, et al.
Publicado: (2021)

Lumazine Synthase Protein Nanoparticle-Gd(III)-DOTA Conjugate as a T(1) contrast agent for high-field MRI
por: Song, YoungKyu, et al.
Publicado: (2015)

Lanthanide Complexes (Gd(III) and Eu(III)) Based on a DOTA‐TEMPO Platform for Redox Monitoring via Relaxivity
por: Barré, Richard, et al.
Publicado: (2022)

FXYD-3 expression in relation to local recurrence of rectal cancer
por: Loftas, Per, et al.
Publicado: (2016)

FXYD5: Na(+)/K(+)-ATPase Regulator in Health and Disease
por: Lubarski Gotliv, Irina
Publicado: (2016)

FXYD6 promotes thermal nociception by regulating TRPV1
por: Luo, Hao, et al.
Publicado: (2021)

FXYD6 overexpression in HBV-related hepatocellular carcinoma with cirrhosis
por: Chen, Xiongfei, et al.
Publicado: (2020)

Effect of Gd(3+) Substitution on Thermoelectric Power Factor of Paramagnetic Co(2+)-Doped Calcium Molybdato-Tungstates
por: Sawicki, Bogdan, et al.
Publicado: (2021)

Safety of meglumine gadoterate (Gd-DOTA)-enhanced MRI compared to unenhanced MRI in patients with chronic kidney disease (RESCUE study)
por: Deray, Gilbert, et al.
Publicado: (2012)

FXYD6: a novel therapeutic target toward hepatocellular carcinoma
por: Gao, Qian, et al.
Publicado: (2014)

FXYD5 Is an Essential Mediator of the Inflammatory Response during Lung Injury
por: Brazee, Patricia L., et al.
Publicado: (2017)

Expression mode and prognostic value of FXYD family members in colon cancer
por: Jin, Ming, et al.
Publicado: (2021)

Epigenetic remodelling of Fxyd1 promoters in developing heart and brain tissues
por: Cuomo, Mariella, et al.
Publicado: (2022)

The earliest evidence for modern-style plate tectonics recorded by HP–LT metamorphism in the Paleoproterozoic of the Democratic Republic of the Congo
por: François, Camille, et al.
Publicado: (2018)

To be or not to be oxidized: A case study of olivine behavior in the fusion crust of ureilite A 09368 and H chondrites A 09004 and A 09502
por: Pittarello, Lidia, et al.
Publicado: (2019)

(111)In-exendin Uptake in the Pancreas Correlates With the β-Cell Mass and Not With the α-Cell Mass
por: Brom, Maarten, et al.
Publicado: (2015)

Overexpression of FXYD-3 Is Involved in the Tumorigenesis and Development of Esophageal Squamous Cell Carcinoma
por: Zhu, Zhen-Long, et al.
Publicado: (2013)

Renal Mg handling, FXYD2 and the central role of the Na,K‐ATPase
por: Mayan, Haim, et al.
Publicado: (2018)

FXYD protein isoforms differentially modulate human Na/K pump function
por: Meyer, Dylan J., et al.
Publicado: (2020)

Effect of differentiation, de novo innervation, and electrical pulse stimulation on mRNA and protein expression of Na(+),K(+)-ATPase, FXYD1, and FXYD5 in cultured human skeletal muscle cells
por: Jan, Vid, et al.
Publicado: (2021)

Safety of Gadoterate Meglumine (Gd-DOTA) as a Contrast Agent for Magnetic Resonance Imaging: Results of a Post-Marketing Surveillance Study in Japan
por: Ishiguchi, Tsuneo, et al.
Publicado: (2012)

Cannot write session to /tmp/vufind_sessions/sess_r31i4me5qj7vlfactfmb15u6rh