Direct Asymmetric Reductive Amination for the Synthesis of (S)-Rivastigmine

In this article we demonstrate how asymmetric total synthesis of (S)-rivastigmine has been achieved using direct asymmetric reductive amination as the key transformation in four steps. The route started with readily available and cheap m-hydroxyacetophenone, through esterification, asymmetric reduct...

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Detalles Bibliográficos
Autores principales: Gao, Guorui, Du, Shaozhi, Yang, Yang, Lei, Xue, Huang, Haizhou, Chang, Mingxin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6225309/
https://www.ncbi.nlm.nih.gov/pubmed/30200331
http://dx.doi.org/10.3390/molecules23092207

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6225309/
https://www.ncbi.nlm.nih.gov/pubmed/30200331
http://dx.doi.org/10.3390/molecules23092207

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