Iodide/H(2)O(2) Catalyzed Intramolecular Oxidative Amination for the Synthesis of 3,2′-Pyrrolidinyl Spirooxindoles

An ammonium iodide/hydrogen peroxide-mediated intramolecular oxidative amination of 3-aminoalkyl-2-oxindoles was achieved, affording the corresponding 3,2′-pyrrolidinyl spirooxindoles and their 6- or 7-membered analogous in moderate to high yields. This metal-free procedure features very mild reacti...

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Autores principales: Gao, Yu-Ting, Jin, Xiao-Yang, Liu, Qi, Liu, An-Di, Cheng, Liang, Wang, Dong, Liu, Li
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6225319/
https://www.ncbi.nlm.nih.gov/pubmed/30189635
http://dx.doi.org/10.3390/molecules23092265
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author Gao, Yu-Ting
Jin, Xiao-Yang
Liu, Qi
Liu, An-Di
Cheng, Liang
Wang, Dong
Liu, Li
author_facet Gao, Yu-Ting
Jin, Xiao-Yang
Liu, Qi
Liu, An-Di
Cheng, Liang
Wang, Dong
Liu, Li
author_sort Gao, Yu-Ting
collection PubMed
description An ammonium iodide/hydrogen peroxide-mediated intramolecular oxidative amination of 3-aminoalkyl-2-oxindoles was achieved, affording the corresponding 3,2′-pyrrolidinyl spirooxindoles and their 6- or 7-membered analogous in moderate to high yields. This metal-free procedure features very mild reaction conditions, non-toxicity and easily handled hydrogen peroxide as a clean oxidant.
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spelling pubmed-62253192018-11-13 Iodide/H(2)O(2) Catalyzed Intramolecular Oxidative Amination for the Synthesis of 3,2′-Pyrrolidinyl Spirooxindoles Gao, Yu-Ting Jin, Xiao-Yang Liu, Qi Liu, An-Di Cheng, Liang Wang, Dong Liu, Li Molecules Article An ammonium iodide/hydrogen peroxide-mediated intramolecular oxidative amination of 3-aminoalkyl-2-oxindoles was achieved, affording the corresponding 3,2′-pyrrolidinyl spirooxindoles and their 6- or 7-membered analogous in moderate to high yields. This metal-free procedure features very mild reaction conditions, non-toxicity and easily handled hydrogen peroxide as a clean oxidant. MDPI 2018-09-05 /pmc/articles/PMC6225319/ /pubmed/30189635 http://dx.doi.org/10.3390/molecules23092265 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Gao, Yu-Ting
Jin, Xiao-Yang
Liu, Qi
Liu, An-Di
Cheng, Liang
Wang, Dong
Liu, Li
Iodide/H(2)O(2) Catalyzed Intramolecular Oxidative Amination for the Synthesis of 3,2′-Pyrrolidinyl Spirooxindoles
title Iodide/H(2)O(2) Catalyzed Intramolecular Oxidative Amination for the Synthesis of 3,2′-Pyrrolidinyl Spirooxindoles
title_full Iodide/H(2)O(2) Catalyzed Intramolecular Oxidative Amination for the Synthesis of 3,2′-Pyrrolidinyl Spirooxindoles
title_fullStr Iodide/H(2)O(2) Catalyzed Intramolecular Oxidative Amination for the Synthesis of 3,2′-Pyrrolidinyl Spirooxindoles
title_full_unstemmed Iodide/H(2)O(2) Catalyzed Intramolecular Oxidative Amination for the Synthesis of 3,2′-Pyrrolidinyl Spirooxindoles
title_short Iodide/H(2)O(2) Catalyzed Intramolecular Oxidative Amination for the Synthesis of 3,2′-Pyrrolidinyl Spirooxindoles
title_sort iodide/h(2)o(2) catalyzed intramolecular oxidative amination for the synthesis of 3,2′-pyrrolidinyl spirooxindoles
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6225319/
https://www.ncbi.nlm.nih.gov/pubmed/30189635
http://dx.doi.org/10.3390/molecules23092265
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