Linking Aromatic Hydroxy Metabolic Functionalization of Drug Molecules to Structure and Pharmacologic Activity

Drug functionalization through the formation of hydrophilic groups is the norm in the phase I metabolism of drugs for the modification of drug action. The reactions involved are mainly oxidative, catalyzed mostly by cytochrome P450 (CYP) isoenzymes. The benzene ring, whether phenyl or fused with oth...

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Detalles Bibliográficos
Autores principales: El-Haj, Babiker M., Ahmed, Samrein B. M., Garawi, Mousa A., Ali, Heyam S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6225321/
https://www.ncbi.nlm.nih.gov/pubmed/30142909
http://dx.doi.org/10.3390/molecules23092119

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6225321/
https://www.ncbi.nlm.nih.gov/pubmed/30142909
http://dx.doi.org/10.3390/molecules23092119

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