Synthesis of Spirooxindole-O-Naphthoquinone-Tetrazolo[1,5-a]Pyrimidine Hybrids as Potential Anticancer Agents

A series of novel spirooxindole-O-naphthoquinone-tetrazolo[1,5-a]pyrimidine hybrids were designed, synthesized and evaluated as potent antitumor agents. These hybrids exhibited relatively high cytotoxic activity against cancer cell line HepG2 (IC(50) = 2.86–36.34 μM), while normal cell line LO2 was...

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Detalles Bibliográficos
Autores principales: Wu, Liqiang, Liu, Yunxia, Li, Yazhen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6225336/
https://www.ncbi.nlm.nih.gov/pubmed/30213123
http://dx.doi.org/10.3390/molecules23092330

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6225336/
https://www.ncbi.nlm.nih.gov/pubmed/30213123
http://dx.doi.org/10.3390/molecules23092330

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