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Synthesis of Spirooxindole-O-Naphthoquinone-Tetrazolo[1,5-a]Pyrimidine Hybrids as Potential Anticancer Agents

A series of novel spirooxindole-O-naphthoquinone-tetrazolo[1,5-a]pyrimidine hybrids were designed, synthesized and evaluated as potent antitumor agents. These hybrids exhibited relatively high cytotoxic activity against cancer cell line HepG2 (IC(50) = 2.86–36.34 μM), while normal cell line LO2 was...

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Detalles Bibliográficos
Autores principales:	Wu, Liqiang, Liu, Yunxia, Li, Yazhen
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6225336/ https://www.ncbi.nlm.nih.gov/pubmed/30213123 http://dx.doi.org/10.3390/molecules23092330

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