Unexpected Resistance to Base-Catalyzed Hydrolysis of Nitrogen Pyramidal Amides Based on the 7-Azabicyclic[2.2.1]heptane Scaffold

Non-planar amides are usually transitional structures, that are involved in amide bond rotation and inversion of the nitrogen atom, but some ground-minimum non-planar amides have been reported. Non-planar amides are generally sensitive to water or other nucleophiles, so that the amide bond is readil...

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Detalles Bibliográficos
Autores principales: Ocampo Gutiérrez de Velasco, Diego Antonio, Su, Aoze, Zhai, Luhan, Kinoshita, Satowa, Otani, Yuko, Ohwada, Tomohiko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6225387/
https://www.ncbi.nlm.nih.gov/pubmed/30223585
http://dx.doi.org/10.3390/molecules23092363

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6225387/
https://www.ncbi.nlm.nih.gov/pubmed/30223585
http://dx.doi.org/10.3390/molecules23092363

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