Cargando…

Ferrocene-Containing Impiridone (ONC201) Hybrids: Synthesis, DFT Modelling, In Vitro Evaluation, and Structure–Activity Relationships

Inspired by the well-established clinical evidence about the interplay between apoptotic TRAIL (tumour necrosis factor-related apoptosis-inducing ligand) mechanism and reactive oxygen species (ROS)-mediated oxidative stress, a set of novel ONC201 hybrids containing the impiridone core and one or two...

Descripción completa

Detalles Bibliográficos
Autores principales:	Bárány, Péter, Oláh, Rita Szabó, Kovács, Imre, Czuczi, Tamás, Szabó, Csenge Lilla, Takács, Angéla, Lajkó, Eszter, Láng, Orsolya, Kőhidai, László, Schlosser, Gitta, Bősze, Szilvia, Mező, Gábor, Hudecz, Ferenc, Csámpai, Antal
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6225426/ https://www.ncbi.nlm.nih.gov/pubmed/30177664 http://dx.doi.org/10.3390/molecules23092248

Ejemplares similares

Novel Polycondensed Partly Saturated β-Carbolines Including Ferrocene Derivatives: Synthesis, DFT-Supported Structural Analysis, Mechanism of Some Diastereoselective Transformations and a Preliminary Study of their In Vitro Antiproliferative Effects
por: Fodor, Kinga Judit, et al.
Publicado: (2020)

Synthesis, structure and in vitro antiproliferative effects of alkyne-linked 1,2,4-thiadiazole hybrids including erlotinib- and ferrocene-containing derivatives
por: Boulhaoua, Mohammed, et al.
Publicado: (2021)

Investigation of the Antitumor Effects of Tamoxifen and Its Ferrocene-Linked Derivatives on Pancreatic and Breast Cancer Cell Lines
por: Kalabay, Márton, et al.
Publicado: (2022)

Synthesis and Antiproliferative Activity of Novel Imipridone–Ferrocene Hybrids with Triazole and Alkyne Linkers
por: Czuczi, Tamás, et al.
Publicado: (2022)

Synthesis, Structure and In Vitro Cytotoxic Activity of Novel Cinchona—Chalcone Hybrids with 1,4-Disubstituted- and 1,5-Disubstituted 1,2,3-Triazole Linkers
por: Jernei, Tamás, et al.
Publicado: (2019)

The Synergistic Activity of Bortezomib and TIC10 against A2058 Melanoma Cells
por: Takács, Angéla, et al.
Publicado: (2021)

Synthesis and SAR Analysis of Novel 4-Hydroxytamoxifen Analogues Based on Their Cytotoxic Activity and Electron-Donor Character
por: Duró, Cintia, et al.
Publicado: (2022)

Acylated mono-, bis- and tris- Cinchona-Based Amines Containing Ferrocene or Organic Residues: Synthesis, Structure and in Vitro Antitumor Activity on Selected Human Cancer Cell Lines
por: Károlyi, Benedek Imre, et al.
Publicado: (2012)

Phage Display-Based Homing Peptide-Daunomycin Conjugates for Selective Drug Targeting to PANC-1 Pancreatic Cancer
por: Dókus, Levente E., et al.
Publicado: (2020)

Alpha-lipoic acid alters the antitumor effect of bortezomib in melanoma cells in vitro
por: Takács, Angéla, et al.
Publicado: (2020)

The effects of mouthwashes in human gingiva epithelial progenitor (HGEPp) cells
por: Kőhidai, Zsófia, et al.
Publicado: (2022)

Overcharging Effect in Electrospray Ionization Mass Spectra of Daunomycin-Tuftsin Bioconjugates
por: Pethő, Lilla, et al.
Publicado: (2019)

Influence of the Drug Position on Bioactivity in Angiopep-2—Daunomycin Conjugates
por: Pethő, Lilla, et al.
Publicado: (2023)

Apoptotic Effects of Drug Targeting Conjugates Containing Different GnRH Analogs on Colon Carcinoma Cells
por: Lajkó, Eszter, et al.
Publicado: (2019)

Structure–Activity Relationship of HER2 Receptor Targeting Peptide and Its Derivatives in Targeted Tumor Therapy
por: Biri-Kovács, Beáta, et al.
Publicado: (2020)

Drug targeting to decrease cardiotoxicity – determination of the cytotoxic effect of GnRH-based conjugates containing doxorubicin, daunorubicin and methotrexate on human cardiomyocytes and endothelial cells
por: Polgár, Livia, et al.
Publicado: (2018)

Effects of Gonadotropin-Releasing Hormone (GnRH) and Its Analogues on the Physiological Behaviors and Hormone Content of Tetrahymena pyriformis
por: Lajkó, Eszter, et al.
Publicado: (2019)

Targeting the Gastrin-Releasing Peptide Receptor (GRP-R) in Cancer Therapy: Development of Bombesin-Based Peptide–Drug Conjugates
por: Gomena, Jacopo, et al.
Publicado: (2023)

Structural Characterization of Daunomycin-Peptide Conjugates by Various Tandem Mass Spectrometric Techniques
por: Borbély, Adina, et al.
Publicado: (2021)

Impedimetric Analysis of the Effect of Decellularized Porcine Heart Scaffold on Human Fibrosarcoma, Endothelial, and Cardiomyocyte Cell Lines
por: Bäcker, Henrik, et al.
Publicado: (2017)

Comparative cell biological study of in vitro antitumor and antimetastatic activity on melanoma cells of GnRH-III-containing conjugates modified with short-chain fatty acids
por: Lajkó, Eszter, et al.
Publicado: (2018)

Green tea polyphenol tailors cell adhesivity of RGD displaying surfaces: multicomponent models monitored optically
por: Peter, Beatrix, et al.
Publicado: (2017)

Synthesis and Cell Growth Inhibitory Activity of Six Non‐glycosaminoglycan‐Type Heparin‐Analogue Trisaccharides
por: Lisztes, Erika, et al.
Publicado: (2021)

The Disordered EZH2 Loop: Atomic Level Characterization by (1)H(N)- and (1)H(α)-Detected NMR Approaches, Interaction with the Long Noncoding HOTAIR RNA
por: Szabó, Csenge Lilla, et al.
Publicado: (2022)

Population tailored modification of tuberculosis specific interferon-gamma release assay
por: Horvati, Kata, et al.
Publicado: (2016)

Influence of the Dabcyl group on the cellular uptake of cationic peptides: short oligoarginines as efficient cell-penetrating peptides
por: Szabó, Ildikó, et al.
Publicado: (2021)

Evaluation of the Chemical Stability, Membrane Permeability and Antiproliferative Activity of Cyclic Diarylheptanoids from European Hornbeam (Carpinus betulus L.)
por: Felegyi-Tóth, Csenge Anna, et al.
Publicado: (2023)

Tailoring Uptake Efficacy of HSV-1 gD Tailoring Uptake Efficacy of Hsv-1 GD Derived Carrier Peptides
por: Bősze, Szilvia, et al.
Publicado: (2020)

Cytotoxic Activity of α-Aminophosphonic Derivatives Coming from the Tandem Kabachnik–Fields Reaction and Acylation
por: Varga, Petra R., et al.
Publicado: (2023)

Dependence of cancer cell adhesion kinetics on integrin ligand surface density measured by a high-throughput label-free resonant waveguide grating biosensor
por: Orgovan, Norbert, et al.
Publicado: (2014)

Natural Compounds as Target Biomolecules in Cellular Adhesion and Migration: From Biomolecular Stimulation to Label-Free Discovery and Bioactivity-Based Isolation
por: Péter, Beatrix, et al.
Publicado: (2021)

2,3-Dihydroferroceno[3,4]pyrrolo[2,1-b]thiazol-5(8b)-ones: Synthesis, Structure and DFT Study on the Mechanism of Chemo- and Diastereoslective Annulations of (S(p))-2-Formylferrocenecarbonyl Fluoride and (S(p))-2-Formylferrocenecarboxylic Acid
por: Kovács, Zoltán, et al.
Publicado: (2021)

The Potential Diagnostic and Predictive Role of HbA1c in Diabetic, Septic Patients: A Retrospective Single-Center Study
por: Juhász, Imre, et al.
Publicado: (2022)

High-Resolution Adhesion Kinetics of EGCG-Exposed Tumor Cells on Biomimetic Interfaces: Comparative Monitoring of Cell Viability Using Label-Free Biosensor and Classic End-Point Assays
por: Peter, Beatrix, et al.
Publicado: (2018)

Correction to “High-Resolution Adhesion Kinetics of EGCG-Exposed Tumor Cells on Biomimetic Interfaces: Comparative Monitoring of Cell Viability Using Label-Free Biosensor and Classic End-Point Assays”
por: Peter, Beatrix, et al.
Publicado: (2019)

A Study of the Bisphosphonic Derivatives from the Pudovik Reaction of Dialkyl α-Oxophosphonates and >P(O)H Reagents: X-ray Structure and Bioactivity
por: Szalai, Zsuzsanna, et al.
Publicado: (2023)

Targeted tumor therapy by Rubia tinctorum L.: analytical characterization of hydroxyanthraquinones and investigation of their selective cytotoxic, adhesion and migration modulator effects on melanoma cell lines (A2058 and HT168-M1)
por: Lajkó, Eszter, et al.
Publicado: (2015)

Are the Cutaneous Microbiota a Guardian of the Skin’s Physical Barrier? The Intricate Relationship between Skin Microbes and Barrier Integrity
por: Szabó, Kornélia, et al.
Publicado: (2023)

Phosphaalkenylidene bridged ferrocenes
por: Orthaber, Andreas, et al.
Publicado: (2012)

Compositional Analysis of Glycosaminoglycans in Different Lung Cancer Types—A Pilot Study
por: Pál, Domonkos, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_ab707iq6j44hiuago9m632n9pa