Cargando…
HCN Channels: New Therapeutic Targets for Pain Treatment
Hyperpolarization-activated cyclic nucleotide-gated (HCN) channels are highly regulated proteins which respond to different cellular stimuli. The HCN currents (I(h)) mediated by HCN1 and HCN2 drive the repetitive firing in nociceptive neurons. The role of HCN channels in pain has been widely investi...
Autores principales: | Ramírez, David, Zúñiga, Rafael, Concha, Guierdy, Zúñiga, Leandro |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2018
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6225464/ https://www.ncbi.nlm.nih.gov/pubmed/30134541 http://dx.doi.org/10.3390/molecules23092094 |
Ejemplares similares
-
The Insensitivity of TASK-3 K(2)P Channels to External Tetraethylammonium (TEA) Partially Depends on the Cap Structure
por: Concha, Guierdy, et al.
Publicado: (2018) -
Correction: Concha, G., et al. The Insensitivity of TASK-3 K(2)P Channels to External Tetraethylammonium (TEA) Partially Depends on the Cap Structure. Int. J. Mol. Sci. 2018, 19, 2437
por: Concha, Guierdy, et al.
Publicado: (2019) -
TASK-3 Downregulation Triggers Cellular Senescence and Growth Inhibition in Breast Cancer Cell Lines
por: Zúñiga, Rafael, et al.
Publicado: (2018) -
Elucidating the Structural Basis of the Intracellular pH Sensing Mechanism of TASK-2 K(2)P Channels
por: Bustos, Daniel, et al.
Publicado: (2020) -
Discovery of Novel TASK-3 Channel Blockers Using a Pharmacophore-Based Virtual Screening
por: Ramírez, David, et al.
Publicado: (2019)