Antagonistic interaction between Nodal and insulin modulates pancreatic β-cell proliferation and survival

BACKGROUND: Insulin signaling pathway in β-cell is essential to promote β-cells proliferation and survival, while Nodal–ALK7–Smad3 signaling involves β-cells apoptosis. We attempted to address inter-relationship between Nodal and insulin in modulating β-cell proliferation and apoptosis. METHODS: Usi...

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Detalles Bibliográficos
Autores principales: Li, Junfeng, Wang, Zhihong, Ren, Liwei, Fan, Linling, Liu, Wenjuan, Jiang, Yaojing, Lau, Harry K., Liu, Rui, Wang, Qinghua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6225724/
https://www.ncbi.nlm.nih.gov/pubmed/30409165
http://dx.doi.org/10.1186/s12964-018-0288-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6225724/
https://www.ncbi.nlm.nih.gov/pubmed/30409165
http://dx.doi.org/10.1186/s12964-018-0288-0

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