A Tyrosine Switch on NEDD4-2 E3 Ligase Transmits GPCR Inflammatory Signaling

Ubiquitination is essential for protein degradation and signaling and pivotal to many physiological processes. Ubiquitination of a subset of G-protein-coupled receptors (GPCRs) by the E3 ligase NEDD4–2 is required for p38 activation, but how GPCRs activate NEDD4–2 to promote ubiquitinmediated signal...

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Detalles Bibliográficos
Autores principales: Grimsey, Neil J., Narala, Rachan, Rada, Cara C., Mehta, Sohum, Stephens, Bryan S., Kufareva, Irina, Lapek, John, Gonzalez, David J., Handel, Tracy M., Zhang, Jin, Trejo, JoAnn
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6226018/
https://www.ncbi.nlm.nih.gov/pubmed/30232011
http://dx.doi.org/10.1016/j.celrep.2018.08.061

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6226018/
https://www.ncbi.nlm.nih.gov/pubmed/30232011
http://dx.doi.org/10.1016/j.celrep.2018.08.061

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