Cargando…

A Tyrosine Switch on NEDD4-2 E3 Ligase Transmits GPCR Inflammatory Signaling

Ubiquitination is essential for protein degradation and signaling and pivotal to many physiological processes. Ubiquitination of a subset of G-protein-coupled receptors (GPCRs) by the E3 ligase NEDD4–2 is required for p38 activation, but how GPCRs activate NEDD4–2 to promote ubiquitinmediated signal...

Descripción completa

Detalles Bibliográficos
Autores principales:	Grimsey, Neil J., Narala, Rachan, Rada, Cara C., Mehta, Sohum, Stephens, Bryan S., Kufareva, Irina, Lapek, John, Gonzalez, David J., Handel, Tracy M., Zhang, Jin, Trejo, JoAnn
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6226018/ https://www.ncbi.nlm.nih.gov/pubmed/30232011 http://dx.doi.org/10.1016/j.celrep.2018.08.061

Ejemplares similares

A General Method for Site Specific Fluorescent Labeling of Recombinant Chemokines
por: Kawamura, Tetsuya, et al.
Publicado: (2014)

Ubiquitin plays an atypical role in GPCR-induced p38 MAP kinase activation on endosomes
por: Grimsey, Neil J., et al.
Publicado: (2015)

Ubiquitination of alpha-synuclein filaments by Nedd4 ligases
por: Mund, Thomas, et al.
Publicado: (2018)

Comparison of substrate specificity of the ubiquitin ligases Nedd4 and Nedd4-2 using proteome arrays
por: Persaud, Avinash, et al.
Publicado: (2009)

Correction: Ubiquitination of alpha-synuclein filaments by Nedd4 ligases
Publicado: (2018)

NEDD8 Deamidation Inhibits Cullin RING Ligase Dynamics
por: Mohanty, Priyesh, et al.
Publicado: (2021)

Subcellular hot spots of GPCR signaling promote vascular inflammation
por: Birch, Cierra A., et al.
Publicado: (2021)

NEDD4 E3 Ligases: Functions and Mechanisms in Bone and Tooth
por: Xu, Ke, et al.
Publicado: (2022)

P300-mediated NEDD4 acetylation drives ebolavirus VP40 egress by enhancing NEDD4 ligase activity
por: Zhang, Linliang, et al.
Publicado: (2021)

Dlg3 Trafficking and Apical Tight Junction Formation Is Regulated by Nedd4 and Nedd4-2 E3 Ubiquitin Ligases
por: Van Campenhout, Claude A., et al.
Publicado: (2011)

E3 Ligase Nedd4 Promotes Axon Branching by Downregulating PTEN
por: Drinjakovic, Jovana, et al.
Publicado: (2010)

Characterization of the mammalian family of DCN-type NEDD8 E3 ligases
por: Keuss, Matthew J., et al.
Publicado: (2016)

The Mechanism of NEDD8 Activation of CUL5 Ubiquitin E3 Ligases
por: Lumpkin, Ryan J., et al.
Publicado: (2021)

The Role of NEDD4 E3 Ubiquitin–Protein Ligases in Parkinson’s Disease
por: Conway, James A., et al.
Publicado: (2022)

Unraveling the Potential Role of NEDD4-like E3 Ligases in Cancer
por: Jayaprakash, Sujitha, et al.
Publicado: (2022)

The inositol phosphatase MTMR4 is a novel target of the ubiquitin ligase Nedd4
por: Plant, Pamela J., et al.
Publicado: (2009)

NEDD8 links Cullin–Ring ubiquitin Ligase function to the p97 pathway
por: den Besten, Willem, et al.
Publicado: (2012)

A Role for the Ubiquitin Ligase Nedd4 in Membrane Sorting of LAPTM4 Proteins
por: Milkereit, Ruth, et al.
Publicado: (2011)

The E3 ubiquitin ligase NEDD4 is translationally upregulated and facilitates pancreatic cancer
por: Weng, Min, et al.
Publicado: (2017)

E3 Ubiquitin ligase NEDD4 family‑regulatory network in cardiovascular disease
por: Zhang, Ying, et al.
Publicado: (2020)

The Roles of NEDD4 Subfamily of HECT E3 Ubiquitin Ligases in Neurodevelopment and Neurodegeneration
por: Haouari, Shanez, et al.
Publicado: (2022)

Expression and regulatory network of E3 ubiquitin ligase NEDD4 family in cancers
por: Cao, Liangzi, et al.
Publicado: (2023)

SAG/RBX2 is a novel substrate of NEDD4-1 E3 ubiquitin ligase and mediates NEDD4-1 induced chemosensitization
por: Zhou, Weihua, et al.
Publicado: (2014)

Inhibition of NEDD8 and FAT10 ligase activities through the degrading enzyme NEDD8 ultimate buster 1: A potential anticancer approach
por: Tan, Ka-Liong, et al.
Publicado: (2016)

The ubiquitin ligase NEDD4-2/NEDD4L regulates both sodium homeostasis and fibrotic signaling to prevent end-stage renal disease
por: Manning, Jantina A., et al.
Publicado: (2021)

Divergent regulation of α-arrestin ARRDC3 function by ubiquitination
por: Wedegaertner, Helen, et al.
Publicado: (2023)

An siRNA library screen identifies CYLD and USP34 as deubiquitinases that regulate GPCR-p38 MAPK signaling and distinct inflammatory responses
por: Cheng, Norton, et al.
Publicado: (2023)

Characterization of the tubulin-tyrosine ligase
Publicado: (1993)

The Short Isoform of the Ubiquitin Ligase NEDD4L Is a CREB Target Gene in Hepatocytes
por: Fu, Jingqi, et al.
Publicado: (2013)

The Ubiquitin Ligase Nedd4-1 Participates in Denervation-Induced Skeletal Muscle Atrophy in Mice
por: Nagpal, Preena, et al.
Publicado: (2012)

Herpesviruses possess conserved proteins for interaction with Nedd4 family ubiquitin E3 ligases
por: Koshizuka, Tetsuo, et al.
Publicado: (2018)

Angiomotin-Like 1 Links Paramyxovirus M Proteins to NEDD4 Family Ubiquitin Ligases
por: Ray, Greeshma, et al.
Publicado: (2019)

Predicting PY motif-mediated protein-protein interactions in the Nedd4 family of ubiquitin ligases
por: Hatstat, A. Katherine, et al.
Publicado: (2021)

Insights Into the Biological Role of NEDD4L E3 Ubiquitin Ligase in Human Cancers
por: Xie, Shangdan, et al.
Publicado: (2021)

The regulatory roles of the E3 ubiquitin ligase NEDD4 family in DNA damage response
por: Lu, Xinxin, et al.
Publicado: (2022)

Elevated intracellular Na(+) and osmolarity stimulate catalytic activity of the ubiquitin ligase Nedd4-2
por: Persaud, Avinash, et al.
Publicado: (2022)

Structural basis of tubulin tyrosination by tubulin tyrosine ligase
por: Prota, Andrea E., et al.
Publicado: (2013)

Crosslinking-guided geometry of a complete CXC receptor-chemokine complex and the basis of chemokine subfamily selectivity
por: Ngo, Tony, et al.
Publicado: (2020)

GPCR targeting of E3 ubiquitin ligase MDM2 by inactive β-arrestin
por: Yun, Yaejin, et al.
Publicado: (2023)

Transport of LAPTM5 to lysosomes requires association with the ubiquitin ligase Nedd4, but not LAPTM5 ubiquitination
por: Pak, Youngshil, et al.
Publicado: (2006)

Cannot write session to /tmp/vufind_sessions/sess_m0d1d36if6juvp49rg20gjb7sk