International Multisite Study of Human-Induced Pluripotent Stem Cell-Derived Cardiomyocytes for Drug Proarrhythmic Potential Assessment

To assess the utility of human-induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) as an in vitro proarrhythmia model, we evaluated the concentration dependence and sources of variability of electrophysiologic responses to 28 drugs linked to low, intermediate, and high torsades de point...

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Detalles Bibliográficos
Autores principales: Blinova, Ksenia, Dang, Qianyu, Millard, Daniel, Smith, Godfrey, Pierson, Jennifer, Guo, Liang, Brock, Mathew, Lu, Hua Rong, Kraushaar, Udo, Zeng, Haoyu, Shi, Hong, Zhang, Xiaoyu, Sawada, Kohei, Osada, Tomoharu, Kanda, Yasunari, Sekino, Yuko, Pang, Li, Feaster, Tromondae K., Kettenhofen, Ralf, Stockbridge, Norman, Strauss, David G., Gintant, Gary
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6226030/
https://www.ncbi.nlm.nih.gov/pubmed/30257217
http://dx.doi.org/10.1016/j.celrep.2018.08.079

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6226030/
https://www.ncbi.nlm.nih.gov/pubmed/30257217
http://dx.doi.org/10.1016/j.celrep.2018.08.079

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