Constitutional mismatch repair-deficiency: current problems and emerging therapeutic strategies

Mismatch repair (MMR) proteins remove errors from newly synthesized DNA, improving the fidelity of DNA replication. A loss of MMR causes a mutated phenotype leading to a predisposition to cancer. In the last 20 years, an increasing number of patients have been described with biallelic MMR gene mutat...

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Detalles Bibliográficos
Autor principal: Abedalthagafi, Malak
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2018
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6226037/
https://www.ncbi.nlm.nih.gov/pubmed/30459937
http://dx.doi.org/10.18632/oncotarget.26249

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6226037/
https://www.ncbi.nlm.nih.gov/pubmed/30459937
http://dx.doi.org/10.18632/oncotarget.26249

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