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Synergistic effects of BET and MEK inhibitors promote regression of anaplastic thyroid tumors

Anaplastic thyroid cancer (ATC) is an aggressive malignancy with limited options for treatment. Targeting epigenetic modifications via interfering with the interaction between the bromodomain and extra-terminal domain (BET) proteins and acetylated histones by using BET inhibitors (e.g., JQ1) has sho...

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Detalles Bibliográficos
Autores principales: Zhu, Xuguang, Holmsen, Erik, Park, Sunmi, Willingham, Mark C., Qi, Jun, Cheng, Sheue-yann
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6226043/
https://www.ncbi.nlm.nih.gov/pubmed/30459933
http://dx.doi.org/10.18632/oncotarget.26253