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Synergistic effects of BET and MEK inhibitors promote regression of anaplastic thyroid tumors
Anaplastic thyroid cancer (ATC) is an aggressive malignancy with limited options for treatment. Targeting epigenetic modifications via interfering with the interaction between the bromodomain and extra-terminal domain (BET) proteins and acetylated histones by using BET inhibitors (e.g., JQ1) has sho...
Autores principales: | Zhu, Xuguang, Holmsen, Erik, Park, Sunmi, Willingham, Mark C., Qi, Jun, Cheng, Sheue-yann |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Impact Journals LLC
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6226043/ https://www.ncbi.nlm.nih.gov/pubmed/30459933 http://dx.doi.org/10.18632/oncotarget.26253 |
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