Intron retention is a source of neoepitopes in cancer

We present an in silico approach to identify neoepitopes derived from intron retention events in tumor transcriptomes. Using mass spectrometry immunopeptidome analysis, we show that retained intron (RI) neoepitopes are processed and presented on MHC-I on the surface of cancer cell lines. RNA-derived...

Descripción completa

Detalles Bibliográficos
Autores principales: Smart, Alicia C., Margolis, Claire A., Pimentel, Harold, He, Meng Xiao, Miao, Diana, Adeegbe, Dennis, Fugmann, Tim, Wong, Kwok-Kin, Van Allen, Eliezer M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6226333/
https://www.ncbi.nlm.nih.gov/pubmed/30114007
http://dx.doi.org/10.1038/nbt.4239

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6226333/
https://www.ncbi.nlm.nih.gov/pubmed/30114007
http://dx.doi.org/10.1038/nbt.4239

Ejemplares similares