Crystal structures of human ET(B) receptor provide mechanistic insight into receptor activation and partial activation

Endothelin receptors (ET(A) and ET(B)) are class A GPCRs activated by vasoactive peptide endothelins, and are involved in blood pressure regulation. ET(B)-selective signalling induces vasorelaxation, and thus selective ET(B) agonists are expected to be utilized for improved anti-tumour drug delivery...

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Detalles Bibliográficos
Autores principales: Shihoya, Wataru, Izume, Tamaki, Inoue, Asuka, Yamashita, Keitaro, Kadji, Francois Marie Ngako, Hirata, Kunio, Aoki, Junken, Nishizawa, Tomohiro, Nureki, Osamu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6226434/
https://www.ncbi.nlm.nih.gov/pubmed/30413709
http://dx.doi.org/10.1038/s41467-018-07094-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6226434/
https://www.ncbi.nlm.nih.gov/pubmed/30413709
http://dx.doi.org/10.1038/s41467-018-07094-0

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