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Crystal structures of human ET(B) receptor provide mechanistic insight into receptor activation and partial activation
Endothelin receptors (ET(A) and ET(B)) are class A GPCRs activated by vasoactive peptide endothelins, and are involved in blood pressure regulation. ET(B)-selective signalling induces vasorelaxation, and thus selective ET(B) agonists are expected to be utilized for improved anti-tumour drug delivery...
| Autores principales: | , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Nature Publishing Group UK
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6226434/ https://www.ncbi.nlm.nih.gov/pubmed/30413709 http://dx.doi.org/10.1038/s41467-018-07094-0 |